Professor Colin Masters, BMedSc (Hons), MBBS, MD, Hon.DLitt, W.Aust., FRCPath, FRCPA, FFSc, FAA, FTSE, FAHMS, AO Professor Colin Masters is a preeminent figure in the field of neurodegenerative diseases, particularly known for his groundbreaking research in Alzheimer’s disease. As a Professor of Dementia Research at The Florey Institute of Neuroscience and Mental Health at the University of Melbourne, and a consultant at the Royal Melbourne Hospital, he has dedicated over four decades to advancing our understanding of Alzheimer's disease and other related conditions. Masters's notable career began with a focus on Alzheimer’s disease and Creutzfeldt-Jakob disease. His collaborative work with Konrad Beyreuther, notably the discovery of the proteolytic neuronal origin of the Aβ amyloid protein, a key factor in Alzheimer's disease, has been pivotal in the field. This discovery has propelled the development of diagnostic and therapeutic strategies, earning international recognition and numerous awards. Recently, Masters has turned his attention to detailing the natural history of Alzheimer’s disease, laying crucial groundwork for the future of disease-modifying therapies. Career Highlights:Â
Professor of Dementia Research, The Florey Institute, University of MelbourneÂ
Consultant, The Royal Melbourne Hospital and Melbourne HealthÂ
Significant contributor to Alzheimer’s disease research, particularly in collaboration with Konrad BeyreutherÂ
Pioneered studies on the neuronal origin of Aβ amyloid protein in Alzheimer’s diseaseÂ
Research Publications:Â
"Avoiding methodological bias in studies of amyloid imaging results disclosure," Alzheimer's Research and Therapy (2019)Â
"Amyloid and Tau Pathology Associations with Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease," Biological Psychiatry (2020)Â
"COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults," IBRO Reports (2019)Â
"Optimizing red blood cell protein extraction for biomarker quantitation with mass spectrometry," Analytical and Bioanalytical Chemistry (2020)Â
"Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease," Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring (2020)Â
Professor Colin Masters's extensive research and numerous accolades highlight his enduring impact on the field of neurodegenerative diseases. His work not only advances scientific understanding but also provides a foundation for developing effective treatments, making him an invaluable asset in the quest to combat Alzheimer’s disease and related conditions.Â
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